Pragmatic trials revisited: applicability is about individualization
نویسندگان
چکیده
منابع مشابه
Making trials matter: pragmatic and explanatory trials and the problem of applicability
Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly paid great attention to internal validity, much less has been given to applic...
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Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions, Trials can fall into two broad categories: pragmatic and explanatory. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice conditions, whereas explanatory trials aim to test whether an intervention works under optimal situations....
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C linical trials testing the value of therapeutic interventions range between the two extremes of maximal internal or external validity. The former study, often called an efficacy trial, tests a treatment under optimal (that is, near laboratory) conditions, in which features such as the patient sample, the intervention, and the outcome measures are narrowly defined. Their research question is u...
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ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2018
ISSN: 0895-4356
DOI: 10.1016/j.jclinepi.2018.02.003